Florfenicol is approved for the treatment of bovine respiratory disease (BRD) associated with Pasteurella haemolytica, Pasteurella multocida, and Haemophilus somnus. Because florfenicol has activity against a wide range of microorganisms (e.g., Mycoplasma), it may be useful for treating other infections in cattle (or other species) as well, but specific data is limited. Like chloramphenicol, florfenicol is a broad-spectrum antibiotic that has activity against many bacteria. It acts by binding to the 50S ribosome, thereby inhibiting bacterial protein synthesis.